Research progress on anti-tumor mechanism of tumor treating fields
10.3760/cma.j.cn112139-20201202-00836
- VernacularTitle:肿瘤电场治疗抗肿瘤机制的研究进展
- Author:
Yuyang LIU
1
;
Hao WU
;
Jialin LIU
;
Ling CHEN
Author Information
1. 解放军医学院，北京 100853
- Keywords:
Glioblastoma;
Antineoplastic protocols;
Tumor treating fields
- From:
Chinese Journal of Surgery
2021;59(6):558-560
- CountryChina
- Language:Chinese
-
Abstract:
The anti-tumor mechanism of tumor treating fields (TTFields) is mainly through interfering with the dynamics of microtubule subunits in mitosis,which blocks the normal process of cell division and eventually leads to cell death.In recent years,relevant studies have found that TTFields still have immunological,molecular biological and other related anti-tumor mechanisms,and can induce reversible increase of cell membrane and blood-brain barrier permeability,which plays a synergistic role in combination with anti-tumor drugs.With the development of multi-system research,the specific treatment frequency,time and field strength of TTFields in different tumor treatments will be revealed.These research progress will further expand the application field of TTFields and benefit more patients.
