Analysis of pathogen distribution and drug resistance of acute,delayed and chronic periprosthetic joint infection
10.3760/cma.j.cn112139-20201224-00883
- VernacularTitle:急性、迟发性和慢性假体周围感染的病原菌分布及耐药性分析
- Author:
Licheng ZHOU
1
;
Guoqing LI
;
Boyong XU
;
Asihaerjiang MAMTIMIN
;
Li CAO
;
Xiaogang ZHANG
Author Information
1. 新疆医科大学第一附属医院关节外科，乌鲁木齐830054
- Keywords:
Prosthesis-related infections;
Arthroplasty,replacement,hip;
Arthroplasty,replacement,knee;
Pathogen;
Antibiotics
- From:
Chinese Journal of Surgery
2021;59(6):484-490
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the pathogen distribution and drug resistance in acute,delayed and chronic periprosthetic joint infection (PJI).Methods:The clinical data of 316 patients with periprosthetic infection after primary hip and knee arthroplasty admitted to the Department of Arthroplasty,the First Affiliated Hospital,Xinjiang Medical University from August 2010 to August 2020 were retrospectively analyzed.There were 146 males and 170 females,aged (62.3±14.2) years (range:22 to 89 years).One hundred and sixty one patients underwent total hip arthroplasty and 155 patients underwent total knee arthroplasty.According to the time of postoperative infection,the patients were divided into acute PJI group (65 cases),delayed PJI group (83 cases) and chronic PJI group (168 cases).The results of pathogen species,composition ratio and drug susceptibility tests were collected,and the independent sample t test,Chi-square test or Fisher′s exact probability test were used for comparison. Results:Gram-positive bacteria were the main pathogens of PJI (49.7%,157/316),and the positive rates of culture in patients with acute PJI,delayed PJI and chronic PJI were 33.8% (22/65),55.4% (46/83) and 53.0% (89/168),and the difference was statistically significant(χ2=8.343, P=0.015).The common bacteria were coagulase-negative Staphylococcus (54.8%,86/157) and Staphylococcus aureus (30.6%,48/157),The drug-sensitivity to linezolid,vancomycin and tigacycline was 100%.The gram-negative bacteria were mainly Escherichia coli and Enterobacter cloacae,and the drug resistance rate to carbapenems was low,ranging from 0 to 9.09%.The drug resistance rates of acute PJI patients to rifampicin,ciprofloxacin and erythromycin were significantly higher than those of late onset and chronic PJI patients,the difference was statistically significant(rifampicin:χ2=14.332, P=0.001;ciprofloxacin:χ2=12.086, P=0.002;erythromycin:χ2=9.096, P=0.010);The drug resistance rate of acute PJI patients to levofloxacin,clindamycin and tetracycline was higher than that of chronic PJI patients,and the difference was statistically significant(levofloxacin:χ2=10.500, P=0.002; clindamycin: χ2=7.103, P=0.007; tetracycline: χ2=6.909, P =0.012).The resistance rate of ampicillin/sulbactam in acute PJI (60.0%) was significantly higher than that in chronic PJI (16.7%),and the difference was statistically significant(χ2= 5.853, P=0.040). Conclusion:Gram-positive bacteria are the main pathogens of PJI,and the resistance rate of pathogens of acute PJI is higher than that of late onset and chronic PJI.
