Solitary pulmonary capillary hemangioma of adult: a series of 10 cases
10.3760/cma.j.cn112139-20200821-00658
- VernacularTitle:孤立性肺毛细血管瘤10例临床分析
- Author:
Yiming ZHOU
1
;
Jie DAI
;
Xiaoxiong XU
;
Yuming ZHU
;
Gening JIANG
;
Liping ZHANG
Author Information
1. 同济大学附属上海市肺科医院胸外科 200433
- Keywords:
Lung neoplasms;
Capillaries;
Solitary pulmonary capillary hemangioma;
Thoracoscopy;
Diagnosis
- From:
Chinese Journal of Surgery
2021;59(1):66-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the clinical features, diagnostic and therapeutic strategy of solitary pulmonary capillary hemangioma (SPCH).Methods:The data of 10 SPCH cases who underwent surgical operations from June 2017 to June 2020 in Shanghai Pulmonary Hospital, Tongji Universitywere retrospectively reviewed. There were 4 males and 6 females, aged (49.8±13.6) years (range: 26 to 66 years). The clinical manifestations, imaging manifestations, treatment and pathological diagnosis were analyzed. Results:All patients were asymptomatic, and all nodules were detected by CT. The size of nodule was (14.9±5.8) mm (range: 8 to 30 mm). Seven of 10 cases showed the mixed ground-glass nodule appearance and 2 cases showed solid nodule and 1 case showed cystic solid nodule appearance in CT findings. The growth speed was very slow. The follow-up time was 4.5(21.5) months before surgery. Histologically, SPCH manifested as a solitary lesion composed of densely proliferating and dilated capillaries without cytologic atypia within the alveolar septa. Immunohistochemically, capillaries of SPCH uniformly expressed endothelial markers, such as CD31, CD34. The patients were followed up for 15.0(22.0) months after surgery and all recovered well.Conclusions:SPCH is probably an unrecognized benign capillary proliferative disease. SPCH lesions mimic early lung cancer on CT as mixed ground-glass nodule, may be misdiagnosed as other nonspecific benign lesions. With careful histologic examination, SPCH can be successfully diagnosed using CD34 or CD31 immunohistochemistry staining.
