Application of autologous platelet-rich plasma separation in cardiac valve replacement: a random clinical trial
10.3760/cma.j.cn112139-20191231-00647
- VernacularTitle:自体富血小板血浆分离技术应用于心脏瓣膜置换术的临床随机对照研究
- Author:
Xiaoyu ZHOU
1
;
Lingfeng XU
;
Xin CHANG
;
Lin SUN
;
Zhen GUO
Author Information
1. 上海市胸科医院 上海交通大学附属胸科医院心外科 200030
- Keywords:
Blood transfusion, autologous;
Heart valve prosthesis implantation;
Platelet-rich plasma
- From:
Chinese Journal of Surgery
2020;58(12):924-928
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the blood protective effect of autologous platelet-rich plasma separation for cardiac valve replacement under cardiopulmonary bypass.Methods:Sixty patients who underwent cardiac valve replacement under cardiopulmonary bypass from August 2018 to May 2019 in Shanghai Chest Hospital, Shanghai Jiao Tong University were randomly divided into control and treatment groups(each 30 cases). There were 33 males and 27 females, aged (52.0±8.4) years (range: 35 to 65 years). Autologous platelet separation was performed in the treatment group after anaesthesia administration and was completed before systemic heparinisation. Platelet separation was not performed in the control group. The thromboelastogram, blood routine, blood coagulation, perioperative fluid infusion, allogeneic blood transfusion, postoperative pleural fluid volume and postoperative fibrinogen were recorded before the operation, and 1 hour and 24 hours post operation. The two groups′ data was compared by t test, Kruskal-Wallis test, Mann-Whitney U test or χ 2 test. Repeated measurement analysis of variance was used to compare platelet and coagulation indexes at different times. Results:The perioperative red blood cell transfusion of 0, 1~2, 3~4,>4 units with 6, 11, 1, 12 cases in treatment group and 14, 8, 6, 2 cases in control group ( Z=-2.516, P=0.012). The postoperative fibrinogen of 0, 1, 2 units with 19, 2, 9 cases in treat group and 26, 2, 2 cases in control group ( Z=-2.190, P=0.029). There was no significant difference in the cost of blood transfusion between the two groups during admission ((1 732±1 275) yuan vs. (1 176±941) yuan; t=-1.570, P=0.125). Conclusion:The use of autologous platelet-rich plasma separation can reduce the amount of allogeneic blood transfusion during valvular surgery under cardiopulmonary bypass.
