Tissue distribution of marbofloxacin in pigs after a single intramuscular injection.
10.4142/jvs.2017.18.2.169
- Author:
Fan YANG
1
;
Yiming LIU
;
Zhili LI
;
Yuqin WANG
;
Baobao LIU
;
Zhensheng ZHAO
;
Bianhua ZHOU
;
Guoyong WANG
Author Information
1. College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China. yfscau@126.com
- Publication Type:Original Article
- Keywords:
kinetic parameters;
marbofloxacin;
pigs;
tissue distribution
- MeSH:
Body Weight;
Chromatography, Liquid;
Half-Life;
Heart;
Injections, Intramuscular*;
Kidney;
Liver;
Lung;
Plasma;
Swine*;
Tissue Distribution*
- From:Journal of Veterinary Science
2017;18(2):169-173
- CountryRepublic of Korea
- Language:English
-
Abstract:
Tissue distribution of marbofloxacin was studied in pigs after a single intramuscular injection at 2.5 mg/kg body weight. Samples of plasma, muscle, liver, kidney, heart, lung, and muscle at the injection site were randomly collected from five pigs at 2, 6, 10, 24, 48, 72, and 96 h after administration. Marbofloxacin concentrations were determined by using high-performance liquid chromatography with ultraviolet detection and were subjected to non-compartmental analysis to obtain kinetic parameters. The elimination half-life (t(1/2λz)) of marbofloxacin at the injection site was 22.12 h, while those in kidney, plasma, liver, lung, heart, and muscle were 16.75, 21.48, 21.84, 24.00, 24.45, and 28.91 h, respectively. Areas under the concentration-time curve from 0 h to (∞) (AUC(0–∞)s) were calculated to be 31.17 h·µg·mL⁻¹ for plasma and 32.97, 33.92, 34.78, 37.58, 42.02, and 98.80 h·µg·g⁻¹ for heart, muscle, lung, liver, kidney, and injection site, respectively. The peak concentration (C(max)) of marbofloxacin was 1.62 µg/mL in plasma and 1.71, 1.74, 1.86, 1.93, 2.45, and 7.64 µg/g in heart, lung, muscle, kidney, liver, and injection site, respectively. The results show that marbofloxacin was fast absorbed, extensively distributed, and slowly eliminated from pigs after a single intramuscular administration.
