Relation of p16 and nm23-H1 protein expression to the biological characteristics of gastric cancer
10.3760/j:issn:0529-5815.2001.03.019
- VernacularTitle:p16和nm23-H1蛋白的表达与胃癌生物学特性的关系
- Author:
Kaixi FAN
1
;
SHAOPING WANG
;
Wenmei LI
Author Information
1. Shangdong Tumor Hospital
- From:
Chinese Journal of Surgery
2001;39(3):229-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the expression of p16 and nm23-H1 and clinicopathology in the patients with gastric cancer. Methods p16 and nm23-H1 protein in cancer tissue of 65 patients were observed with labelled streptavidin biotin (LSAB) immunohistochemical method. Results The total positive rate of p16 and nm23-H1 was 30.8% and 41.5% respectively in gastric cancer tissues. The positive expression rate of p16 was significantly higher in well-differentiated cancer than in poorly-differentiated cancer (P＜0.05). The positive expression rate of p16 and nm23-H1 was higher in patients with lymph node metastasis than in those without lymph node metastasis(P＜0.05，P＜0.01) and in clinical stage Ⅰ,Ⅱ than in stage Ⅲ (P＜0.05，P＜0.01).The 3-year survival rate was higher in positive cases of p16 or nm23-H1 protein expression (45.0%，51.9%）than in negative ones（28.9%、21.1%）(P＜0.05).There was a significants positive correlation between p16 and nm23-H1 protein expression(r=0.041*!5,P＜0.05). Conclusions p16 and nm23-H1 may play a role in the development of gastric cancer and be related to partial biological behavior. Expression of p16 and nm23-H1 may serve as a marker for predicting the cancer metastasis and evaluating the prognosis of gastric cancer patients.
