Intracranial arteriovenous malformation animal model:creation and embolization
10.3760/j:issn:0529-5815.2001.03.002
- VernacularTitle:颅内动静脉畸形动物模型制作与栓塞的实验研究
- Author:
Daming WANG
1
;
Feng LING
;
Anshun WANG
;
Dongge LIU
;
Meng LI
;
Hongqi ZHANG
;
Zhongrong MIAO
Author Information
1. 卫生部北京医院
- From:
Chinese Journal of Surgery
2001;39(3):179-181
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the creation of intracranial arteriovenous malformation (AVM) animal model and its application in embolization. Methods Using their rete mirabile (ReM) as nidus of AVM, we selected nine Chinese Experimental Mini-pigs (CEMPs) to create AVM animal models mainly by right carotid-jugular anastomosis (CJA) and ligation of the right external carotid artery. The models were embolized respectively with n-butal 2-cyanoacrylate and embosphere, and the ReM, CJA vessel and brain of the animal were removed for histopathological observation. Angiographies were arranged before and after model creation as well as pre- and post embolization. Combined with angio-images and histopathological findings, the applications of the model, the reason of CJA stoma occlusion, and the possibility of model improvement were discussed. Results The AVM animal model was successfully created in seven CEMPs, which was similar to human brain AVM in angio-architecture, angiographic-image, embolizing behavior and post embolization pathological findings. Thromboses were found inside the CJA vessels in 4 animals and in the rest 3 the CJA vessels were shrunk without thrombus. The brain histopathological changes of the dead animal after embolization were of ischemic infarction. Conclusions Although our method is relatively more simple and rather reliable, which is suitable for the embolizing research of embolic agents and for the training of interventional staff, it reaches however an acute (short-term) model and its applications are evidently limit. How to prevent the CJA stoma occlusion and to let animal tolerate the embolization need further studies.
