Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor.
10.4142/jvs.2017.18.2.257
- Author:
Yawon HWANG
1
;
Dongwook KIM
;
Dongwoo CHANG
;
Byeongwoo AHN
;
Yun Bae KIM
;
Gonhyung KIM
Author Information
1. Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea. ghkim@cbu.ac.kr
- Publication Type:Case Report
- Keywords:
flucytosine;
gene therapy;
metastatic lung tumor;
neural stem cells
- MeSH:
Drug Therapy;
Flucytosine*;
Genetic Therapy;
Humans;
Lung*;
Neural Stem Cells*;
Quality of Life;
Therapeutic Uses
- From:Journal of Veterinary Science
2017;18(2):257-260
- CountryRepublic of Korea
- Language:English
-
Abstract:
This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared approximately two weeks after 5-FC administration. Thoracic radiographs revealed a reduced number of lung nodules and decreased nodule size. However, there were no significant antitumor effects on primary lesions in abdominal organs. In conclusion, human NSC/5-FC prodrug therapy can secure patient quality of life with the same or more therapeutic effects and fewer side effects than other recommended chemotherapies.
