Predictive factors for pathological complete response to neoadjuvant therapy in locally advanced rectal cancer: a review of current research
10.3760/cma.j.cn441530-20240726-00260
- VernacularTitle:局部进展期直肠癌新辅助治疗病理完全缓解预测因素的研究现状
- Author:
Ruoxi TIAN
1
;
Jiyun LI
;
Pu CHENG
;
Fei HUANG
;
Qian LIU
;
Zhaoxu ZHENG
Author Information
1. 中国医学科学院肿瘤医院结直肠外科，北京 100021
- Keywords:
Rectal neoplasms, locally advanced;
Neoadjuvant therapy;
Pathological complete response;
Predictive factors
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(10):1083-1091
- CountryChina
- Language:Chinese
-
Abstract:
The guidelines advocate for preoperative neoadjuvant radiotherapy and chemotherapy in cases of middle and low locally advanced rectal cancer. While some patients achieved pathological complete response (pCR), which is favorable and allows for potential organ preservation, treatment sensitivity varies and not all patients reach pCR. Identifying the factors influencing pCR is important for enhancing the effectiveness of neoadjuvant therapy and improving patient outcomes. Previous research has identified various factors associated with response to neoadjuvant therapy, which can serve as predictors of pCR. This study reviews recent literature on imaging, pathological, genetic, and molecular characteristics, laboratory indices, and therapeutic factors related to tumor response, both domestically and internationally. The aim is to summarize the latest advancements in understanding the factors associated with pCR in patients with locally advanced middle and low rectal cancer undergoing neoadjuvant therapy, thereby providing a theoretical foundation for standardized clinical treatment approaches.
