Treatment strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for gastric cancer with peritoneal metastasis: a systematic review
10.3760/cma.j.cn441530-20230831-00076
- VernacularTitle:细胞减灭术联合腹腔热灌注化疗在胃癌腹膜转移中的治疗策略的系统综述
- Author:
Chenghao JI
1
;
Linpo ZHOU
;
Yebin YANG
;
Junqiang HU
;
Haoran WEI
;
Fanhe DONG
;
Yuqiang SHAN
;
Wencheng KONG
Author Information
1. 浙江中医药大学第四临床医学院，杭州 310053
- Keywords:
Peritoneal metastasis;
Stomach neoplasms;
Hyperthermic intraperitoneal chemotherapy;
Cytoreductive surgery
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(7):740-748
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal metastasis in gastric cancer is associated with rapid disease progression. Hyperthermic intraoperative peritoneal chemotherapy (HIPEC) done immediately after cytoreductive surgery (CRS) has become an important treatment for peritoneal metastasis in gastric cancer patients. However, different treatment options for HIPEC exist with potential influence on survival rates and prognosis in patients, exist. These treatment options include open or closed abdomen technique, perfusion solution, number of catheters, temperature, duration, and drug regimens. This paper aims to provide more evidence on standardization of HIPEC treatment options and technologies by systematically reviewing different drug regimens and technical approaches. The study included 2 randomized controlled trials, 3 phase I/II clinical trials, 2 prospective cohort studies, and 34 retrospective cohort studies, involving 1511 patients. The most common HIPEC option is to dissolve 50-75 mg/m 2 of Cisplatin and 30-40 mg/m 2 of Mitomycin C in 3-4 L saline solution at 42-43℃. After gastrointestinal anastomosis, 2-3 catheters are used in the HIPEC system with a perfusion flow rate of 500 ml/min. The duration is 60-90 minutes. Anastomotic leakage was low in studies where HIPEC was performed after gastrointestinal anastomosis. The utilization of open HIPEC and a two-drug regimen resulted in improved overall survival rates. The future development of HIPEC aims to enhance tumor-specific therapy by optimizing various aspects, such as identifying the safest and most effective chemotherapy regimens, refining patient selection criteria, and improving perioperative care.
