Multi-omics research progress in early-onset colorectal cancer

VernacularTitle:早发性结直肠癌的多组学研究进展
Author: Silu CHEN ¹ ; Junyi XIN ; Mulong DU ; Meilin WANG
Author Information

1. 南京医科大学公共卫生学院，南京　211166
Keywords: Colorectal neoplasms, early-onset; Multi-omics research; Integrated analysis
From: Chinese Journal of Gastrointestinal Surgery 2024;27(5):447-451
CountryChina
Language:Chinese
Abstract: Globally, the incidence of early-onset colorectal cancer (EOCRC) among individuals younger than 50 is escalating. Compared to late-onset colorectal cancer, EOCRC exhibits distinct clinical, pathological, and molecular features, with a higher prevalence in the left colon and rectum. However, the occurrence and development of EOCRC is a multi-factor and multi-stage evolution process, which is the result of the mutual effect of environmental, genetic and biological factors, and involves the multi-level regulation mechanism of other organisms. With the development and improvement of high-throughput sequencing technology, the application of multi-omics analysis has become an important development direction to resolve the pathogenesis of complex diseases and individualized treatment plans. This article aims to review the research progress of EOCRC at the multi-omics level, providing a theoretical foundation for earlier diagnosis and more precise treatment of this diseases.