Advances of hydrogel in early protection of exposed intra-abdominal organs after open abdomen

VernacularTitle:水凝胶保护腹腔开放创面的研究进展
Author: Canwen CHEN ¹ ; Kang CHEN ; Ze LI ; Yungang JIANG ; Guiwen QU ; Ye LIU ; Sicheng LI ; Jinjian HUANG ; Xiuwen WU ; Jian'an REN
Author Information

1. 东部战区总医院普通外科　全军普通外科研究所　南京大学医学院附属金陵医院，南京　210002
Keywords: Open abdomen; Wound protection; Enteroatmospheric fistula; Biomimetic peritoneal material; Hydrogel
From: Chinese Journal of Gastrointestinal Surgery 2023;26(9):898-902
CountryChina
Language:Chinese
Abstract: The protection of open abdomen (OA) wound is a significant subject in the field of trauma surgery. The key technical challenge in the early stage of OA wound management involves promoting granulation tissue filling between intestinal segments, reducing intestinal wall abrasion, and preventing the development of enteroatmospheric fistulas (EAF). Hydrogels, characterized by their high water content and exceptional biocompatibility, serve as extracellular matrix-mimicking materials, and are extensively employed in various medical and healthcare applications. In this review, we discuss the application of hydrogel developed by natural biomaterials in OA wounds protection, taking into consideration the unique pathophysiological characteristics of the OA wounds. This review aims to provide valuable insights for the development of hydrogel materials for early-stage OA wound protection in future research.