The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study.
- Author:
Kyeong A SO
1
;
Mi Jung KIM
;
Ki Heon LEE
;
In Ho LEE
;
Mi Kyung KIM
;
Yoo Kyung LEE
;
Chang Sun HWANG
;
Mi Seon JEONG
;
Mee Kyung KEE
;
Chun KANG
;
Chi Heum CHO
;
Seok Mo KIM
;
Sung Ran HONG
;
Ki Tae KIM
;
Won Chul LEE
;
Jong Sup PARK
;
Tae Jin KIM
Author Information
- Publication Type:Original Article
- Keywords: Human papillomavirus; Genotype; Cytology
- MeSH: Atypical Squamous Cells of the Cervix; Cohort Studies*; Female; Genotype*; Human papillomavirus 16; Human Papillomavirus DNA Tests; Humans; Squamous Intraepithelial Lesions of the Cervix
- From:Cancer Research and Treatment 2016;48(4):1313-1320
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The purpose of this study is to evaluate the impact of high-risk human papillomaviruses (HPVs) other than HPV 16/18 on the natural course of atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL). MATERIALS AND METHODS: The study population was derived from the Korean HPV cohort (2010-2014). Women aged 20 to 60 who satisfied the criteria of having both HPV infection and abnormal cervical cytology of either ASC-US or LSIL were recruited from five institutions nationwide. Enrolled patients underwent cervical cytology and HPV DNA testing every 6 months. RESULTS: A total of 1,158 patients were enrolled. The 10 most common HPV types were HPV 16 (12.3%), 58 (10.0%), 56 (8.8%), 53 (8.4%), 52 (7.7%), 39 (6.2%), 18 (6.0%), 51 (5.7%), 68 (5.1%), and 66 (4.6%). Among these patients, 636 women were positive for high-risk HPVs other than HPV 16 or 18, and 429 women were followed for more than 6 months. Cytology evaluations showed progression in 15.3% of women, no change in 22.6%, and regression in 62.1% of women at 12 months. In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001). CONCLUSION: HPV genotypes numbered in the 50s were frequent in Korean women with ASC-US and LSIL. HPV 58 was the second most common type, with a high progression rate of cervical cytology.
