Research advance of liquid biopsy in gastrointestinal stromal tumors

VernacularTitle:液体活检在胃肠间质瘤中的研究进展
Author: Jianyi SUN ¹ ; Xiaodong GAO ; Kuntang SHEN
Author Information

1. 复旦大学附属中山医院普通外科，上海　200032
Keywords: Gastrointestinal stromal tumor; Liquid biopsy; Exosome
From: Chinese Journal of Gastrointestinal Surgery 2020;23(9):917-921
CountryChina
Language:Chinese
Abstract: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumors in the gastrointestinal tract. Surgical resection is the only curative treatment, while imatinib is the first-line therapy for recurrent, metastatic, and unresectable GIST. However, more than half of GIST patients suffer from secondary resistance to imatinib within 2 years after treatment initiation. Therefore, early diagnosis, drug resistance and recurrence surveillance are critical for GIST patients. Liquid biopsy is a new method which utilizes the detection of tumor biomarkers in peripheral blood for early diagnosis and therapeutic efficacy assessment. In recent years, liquid biopsy has achieved significant research progress in several kinds of malignancy. This review aims at presenting an overview on research advance of liquid biopsy in GIST and may provide a new method for early diagnosis and therapeutic efficacy assessment of GIST.