Application of imaging diagnosis in watch and wait strategy for locally advanced rectal cancer patients after neoadjuvant therapy
10.3760/cma.j.cn.441530-20200224-00078
- VernacularTitle:影像诊断在直肠癌新辅助治疗后等待观察策略中的应用
- Author:
Xiaoyan ZHANG
1
;
Qiaoyuan LU
;
Yingshi SUN
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所 恶性肿瘤发病机制及转化研究教育部重点实验室 医学影像科 100142
- Keywords:
Rectal neoplasms;
Imaging;
Neoadjuvant therapy;
Complete response;
Watch and wait strategy
- From:
Chinese Journal of Gastrointestinal Surgery
2020;23(3):243-247
- CountryChina
- Language:Chinese
-
Abstract:
After neoadjuvant chemoradiotherapy(nCRT), 15%-40% of rectal cnacers has a pathological complete response (pCR), with non-malignant cells demonstrated in histological assessment of the surgical resection specimen. Since these patients have excellent oncological outcomes, there has been a rapidly growing interest in organ preservation for those who achieve a clinical complete response (cCR), that is "Watch and Wait strategy" (W&W). One of the major challenges in the W&W of rectal cancer is the careful and precise selection of patients suitable for this approach. The published series on W&W has all used different modalities to assess response post nCRT, including the MSKCC′s three-tiered evaluation plan and Mercury′s mrTRG criteria. Except significant heterogeneous results, the evidence available comes mostly from retrospective cohort studies, furthermore, there is a lack of data of long-term outcomes. How to accurately screen pCR patients preoperatively is an important and difficult issue of clinical concern.
