Disputes and exploration of neoadjuvant and adjuvant therapy for colon cancer
10.3760/cma.j.issn.1671?0274.2019.04.004
- VernacularTitle:结肠癌围手术新辅助与辅助治疗之争议与探索
- Author:
Jun LI
1
;
Xinlin LI
;
Ying YUAN
;
Suzhan ZHANG
Author Information
1. 浙江大学医学院附属第二医院肿瘤外科
- Keywords:
Colonic neoplasms;
Perioperative therapy;
Adjuvant therapy;
Neoadjuvant therapy
- From:
Chinese Journal of Gastrointestinal Surgery
2019;22(4):329-335
- CountryChina
- Language:Chinese
-
Abstract:
Perioperative treatment combined with radical resection is the major approach to cure non?metastatic colon cancer. A precise evaluation and perioperative treatment would probably improve the R0 resection rate, recurrence?free survival and overall survival of colon cancer patients. Recently, individualized treatment is the mainstream due to the development of molecular pathology and multi ? disciplinary therapy. The indications and course of perioperative treatment and preoperative neoadjuvant therapy of colon cancer are still in intense discussion. The present review will mainly discuss three topics. Firstly, the various reaction of adjuvant therapy to stage II colon cancer is caused by patients′ heterogeneity. Choosing stratified treatment for these patients according to clinical and molecular pathological features is the future. Secondly, we discuss the adjuvant chemotherapy course for stage III colon cancer according to the Chinese Society of Clinical Oncology (CSCO) guideline and the progress of this field. Lastly, we summarize the status and significance of colon cancer neoadjuvant therapy.
