Clinical efficacy observation of cetuximab combined with chemotherapy in the treatment of metastatic colorectal carcinoma
10.3760/cma.j.issn.1671-0274.2015.06.017
- VernacularTitle:西妥昔单抗联合化疗治疗转移性结直肠癌的临床疗效观察
- Author:
Tingting ZHANG
1
;
Dan SU
;
Juan LI
;
Yishang WANG
;
Chun HAN
;
Shunchang JIAO
;
Li BAI
Author Information
1. 解放军总医院肿瘤内一科
- Keywords:
Colorectal neoplasms,metastasis;
Cetuximab;
Chemotherapy
- From:
Chinese Journal of Gastrointestinal Surgery
2015;(6):584-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of cetuximab plus chemotherapy in the treatment of metastatic colorectal carcinoma. Methods Clinicopathological data of 128 patients with metastatic colorectal cancer admitted in the Department of Oncology , Chinese PLA General Hospital from 2008 to June 2012 were analyzed retrospectively. Among them, 91 patients received cetuximab as the first-line therapy and 37 in the second-line or more-line therapy. The chemotherapy regimens included oxaliplatin-based therapy (FOLFOX/XELOX), irinotecan-based therapy (FOLFIRI/XELIRI) and fluorouracil-based therapy (Xeloda). The efficacy was evaluated according to RECIST 1.0 criteria. The remission rate, control rate and time to disease progression were compared among patients receiving cetuximab combined with different chemotherapy regimens in different periods. Results The disease control rate of cetuximab applied in the first-line treatment was higher than that of the second-line or more-line [85.9%(61/71) vs. 59.3%(16/27), P=0.004]. The disease control rate of the group treated with cetuximab plus oxaliplatin-based chemotherapy was much higher compared to the other two groups [91.1%(41/45) vs. 68.1%(32/47), 4/6, P=0.021]. But there were no significant differences among three regimens in the terms of overall response rate (all P>0.05). The median time to progression of groups with cetuximab plus irinotecan, oxaliplatin or capecitabine was 7.8 months, 8.5 months and 5.2 months respectively. The median time to progression of cetuximab combined with chemotherapy in the first-line treatment and the second-line or more-line was 8.2 and 7.7 months respectively. However , the differences were not statistically significant (P>0.05). Conclusions Cetuximab in combination with oxaliplatin-based chemotherapy is recommended as the first-line application in the treatment of metastatic colorectal carcinoma patients, because it is helpful to improve the rate of disease control.
