Predictive value of CA125 in peritoneal metastasis and prognosis of patients with gastric carcinoma
10.3760/cma.j.issn.1671-0274.2014.10.017
- VernacularTitle:血清糖类抗原125对胃癌腹膜转移及其预后的预测价值
- Author:
Peng ZHOU
1
,
2
;
Hui QU
;
Huiwen SHI
;
Guorui SUN
;
Qingsi HE
Author Information
1. 250012 济南，山东大学齐鲁医院普通外科
2. 山东省泰州市人民医院泌尿外科
- Keywords:
Stomach neoplasms;
Carbohydrate antigen 125;
Peritoneal metastasis;
Prognosis
- From:
Chinese Journal of Gastrointestinal Surgery
2014;(10):1027-1030
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum CA125 in peritoneal metastasis, and to examine the association of CA125 with the prognosis. Methods Clinical data of 1285 gastric cancer patients admitted to the Qilu Hospital from March 2003 to September 2008 were retrospectively reviewed. The sensitivity, specificity and accuracy of serum CA125 for peritoneal metastasis were analyzed. Clinicopathological characteristics and survival were compared between patients with normal serum CA125 level(≤35 μg/L) and patients with elevated serum CA125 level (> 35 μg/L). Results The specificity, sensitivity and accuracy of serum CA125 for peritoneal metastasis were 96.0%, 13.8% and 81.2%, respectively. A significantly higher incidence of peritoneal metastasis was observed in the patients with elevated serum CA125 level as compared to those with normal serum CA125 level (43.2% vs. 16.5%). CA125 was an independent predictor of peritoneal metastasis (RR=3.475, 95% CI:2.124-5.685). The 5-year overall survival rate in patients with elevated serum CA125 level was 13.5%, which was significantly lower than that of patients with normal serum CA125 level (49.8%, P<0.01). CA125 was an independent prognostic factor of gastric cancers (HR=2.049, 95%CI:1.355-2.873). Conclusion Serum CA125 is useful in predicting peritoneal metastasis and prognosis of gastric cancer , which should be used as a routine examination of gastric cancer patients.
