Analysis of early lymph node metastasis pattern and prognosis in thoracic esophageal squamous cell carcinoma
10.3760/cma.j.issn.1671-0274.2014.09.010
- VernacularTitle:N1期食管鳞癌淋巴结转移规律及预后分析
- Author:
Zhao MA
1
;
Peng TANG
;
Hongdian ZHANG
;
Chuangui CHEN
;
Zhentao YU
Author Information
1. 300060,天津医科大学肿瘤医院食管肿瘤科 国家肿瘤临床医学研究中心 天津市 “肿瘤防治”重点实验室
- Keywords:
Esophageal neoplasms;
Squamous cell carcinoma;
Lymphatic mrtastasis;
Neoplasm staging;
Pronosis
- From:
Chinese Journal of Gastrointestinal Surgery
2014;(9):884-887
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pattern of early lymph node metastasis of thoracic esophageal squamous cell carcinoma and its prognostic value. Methods Clinical and follow-up data of 126 patients with pathological stage pN1 of esophageal squamous cell carcinoma undergoing radical esophagectomy in our department from January 2005 to December 2008 were analyzed retrospectively. Impact of lymph node metastasis pattern on prognosis was investigated. Results The relatively common sites of lymph node metastasis were upper mediastinum ( 53 . 8%) , middle and lower thoracic paraesophageal (38.3%), right and left cardiac (34.4%) and the left gastric artery (36.8%). Univariate analysis showed that the lymph node metastasis of subcarinal , middle and lower thoracic paraesophageal and the left gastric artery was associated with 5-year survival rate. Multivariate analysis revealed that the presence of subcarinal and middle and lower thoracic paraesophagea lymph node metastasis was an independent risk factor of survival. Conclusions Upper mediastinal, middle and lower thoracic paraesophageal, right and left cardiac and the left gastric artery are the earliest lymph node metastasis sites of esophageal squamous cell carcinoma. The presence of subcarinal and middle and lower thoracic paraesophagea lymph node metastasis is an independent risk factor of survival. Patient prognosis should be analyzed with lymph node metastasis pattern based on the 7th edition UICC-AJCC TNM classification system.
