Risk factors associated with lymph node metastasis and prognosis in 69 patients with rectal neuroendocrine tumors
10.3760/cma.j.issn.1671-0274.2014.06.014
- VernacularTitle:直肠神经内分泌肿瘤69例淋巴结转移和预后的影响因素分析
- Author:
Yue CHEN
1
;
Qiang LI
;
Chun SONG
;
Yongpeng WANG
;
Xu WANG
;
Qingkai MENG
;
Rui ZHANG
;
Fang LIU
Author Information
1. 辽宁省肿瘤医院大肠外科
- Keywords:
Rectal neoplasms;
Neuroendocrine tumor;
Lymph node metastasis;
Prognosis
- From:
Chinese Journal of Gastrointestinal Surgery
2014;(6):578-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate risk factors associated with lymph node metastasis and prognosis of rectal neuroendocrine tumor (NET). Methods Clinicopathological data of 69 patients with rectal NET in our department from April 2003 to October 2011 were retrospectively analyzed. Associations of clinicopothological factors with lymph node metastasis and prognosis were examined using univariate and multivariate analysis. Results Of the 69 patients, 9 cases had lymph node metastasis. The lymph node metastasis was significantly associated with tumor size, T stage and G grade by univariate analysis. Multivariate analysis showed that T stage was the only risk factor associated with lymph node metastasis. The overall 5-year survival rate was 90.3%. Prognosis of rectal NET was significantly associated with tumor size, T stage, N stage, M stage, TNM stage and G grade by univariate analysis. Multivariate analysis showed that M stage was significantly associated with long-term survival in rectal NET patients (P=0.000, HR=2.285, 95%CI:1.484~3.518). There was no significant difference in patients with stage Ⅰ between local and radical resection, while there were significant differences in those with stage Ⅱ or higher between the two operations (P=0.046). Conclusion T stage is associated with lymph node metastasis and both TNM stage and M stage can affect the prognosis of patients with NET, which may be used as potential predictive factors for rectal NET. Local resection should be recommended for patients with stage Ⅰ and radical resection should be recommended for patients with stage Ⅱor higher.
