Clincal, MRI and MRA Findings of Cheiro-Oral-Pedal syndrome.
- Author:
Chang Jong MOON
1
;
Jae Jin LEE
;
Hoo Won KIM
;
Won Young JUNG
Author Information
1. Department of Neurology, Chosun University Medical College, 588 Seosuk-dong, Dong-gu, Gwangju, 501-717, Korea. hoowon@mail.chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Cheiro-oral;
Cerebral infarction;
Lacune
- MeSH:
Atherosclerosis;
Brain;
Brain Neoplasms;
Central Nervous System;
Cerebral Infarction;
Constriction, Pathologic;
Follow-Up Studies;
Foot;
Hand;
Hospital Mortality;
Humans;
Intracranial Hemorrhages;
Magnetic Resonance Imaging*;
Male;
Migraine Disorders;
Mouth;
Neurology;
Paresthesia;
Passive Cutaneous Anaphylaxis;
Pathology;
Pons;
Prognosis;
Retrospective Studies;
Risk Factors;
Stroke;
Thalamus;
Ultrasonography
- From:Journal of the Korean Neurological Association
2003;21(2):141-145
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cheiro-oral-pedal syndrome is characterized by a unilateral or bilateral sensory disturbance in mouth corner and hand and/or foot, and associated with central nervous system disease. Causative diseases are cerebral infarction, intracranial hemorrhage, brain tumor, migraine, etc. When related with cerebral infarction, it is known to have lacunar type pathology and favorable prognosis. But other pathogenic mechanism and poor prognosis is suggested. METHODS: We retrospectively studied 12 patients presented with cheiro-oral-pedal syndrome, who visited the department of neurology in Chosun University Hospital from September 2000 to August 2002. Cheiro-oral-pedal syndrome was diagnosed according to the clinical manifestations and brain MRI findings. We assessed neurological findings, brain MRI and MRA findings, duplex sonographic findings, risk factors of stroke and outcome of the patients. Followup period was 3-20 (mean 8) months. RESULTS: There were 12 patients (10 men, 2 women) with the age ranged from 45 to 80 (mean 57.8) years. Sensory loss on cheiro-oral area was present in 8 (66.7%) and on cheiro-oral-pedal area in 4 (33.3%). Responsible lesions were found in thalamus, capsulo-striatum, corona radiata, pons, and fronto-parietal cortex. Three patients had a major cerebral vascular abnormality on MRA. One had MCA stenosis, the other PCA stenosis and another distal ICA stenosis. Sensory symptoms had remained in all patient except one. In-hospital mortality and other neurological deficit at discharge were absent in all. CONCLUSIONS: Cheiro-oral syndrome has mixed pathogenic mechanism of small vessel disease and large vessel atherosclerosis and involves various sites. Paresthesia itself has bad prognosis but overall clinical course is benign.
