Proximal gastrectomy versus total gastrectomy for adenocarcinoma of esophagogastric junction：a meta-analysis
10.3760/cma.j.issn.1671-0274.2014.04.018
- VernacularTitle:近端胃切除与全胃切除对SiewertⅡ~Ⅲ型食管胃结合部癌疗效比较的Meta分析
- Author:
Yingjun LIU
1
;
Guangsen HAN
;
Gangcheng WANG
;
Xiangbin WAN
;
Yingkun REN
;
Yong CHENG
;
Zhiqiang JIANG
Author Information
1. 450008,郑州大学附属肿瘤医院普通外科
- Keywords:
Adenocarcinoma of esophagogastric junction;
Proximal gastrectomy;
Total gastrectomy;
Meta-analysis
- From:
Chinese Journal of Gastrointestinal Surgery
2014;(4):373-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of proximal gastrectomy (PG) and total gastrectomy (TG) for adenocarcinoma of esophagogastric junction. Methods Clinical trials comparing PG with TG for adenocarcinoma of esophagogastric junction published from 1990 to 2012 were searched in Cochrane library, Medline, Embase and China National Knowledge Infrastructure (CNKI), Wanfang Data. Review manager 5.0 was used for meta-analysis and outcome measures included mortality and complication morbidity, as well as nutritional state. Results A total of 10 studies including 2481 patients were identified and analyzed. The results showed no significant differences in the mortality (OR=1.00, P=0.99) and complication morbidity(OR=2.14, P=0.12) between PG and TG. However, anastomotic stenosis (OR=5.40, P<0.01) and reflux esophagitis (OR=7.12, P=0.01) were more frequently observed in PG group. The nutritional state in TG group was comparable with PG group (WMD=2.09, P=0.57). Conclusion TG is superior to PG in reducing the morbidity of anastomotic stenosis and reflux esophagitis.
