Neuroprotective Effect of Genistein Against beta Amyloid-Induced Neurotoxicity.
- Author:
Oh Young BANG
1
;
In Hee MOOK
;
Kyoon HUH
Author Information
1. Department of Neurology, Ajou University, School of Medicine, 5 San Woncheon-dong, Paldal-gu, Suwon-si, 442-749, Korea. nmboy@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Estrogen;
Genistein;
Beta amyloid;
Alzheimer's disease;
Cell death;
Estrogen receptor
- MeSH:
Alzheimer Disease;
Cell Death;
Estrogens;
Genistein*;
Hand;
Humans;
Neuroblastoma;
Neuroprotective Agents*
- From:Journal of the Korean Neurological Association
2003;21(2):174-182
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Estrogen is beneficial to patients with Alzheimer's disease but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal estrogen responsive cells. METHODS: In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor betaagonist, with those of estrogen. RESULTS: Genistein and 17beta-estradiol showed comparable levels of protection against Abeta-induced death of cultured SH-SY5Y human neuroblastoma cells, which was blocked by an estrogen receptor antagonist, ICI 182, 780. On the other hand, 17beta-estradiol, but not geninstein, induced proliferation of uterine endometrial cells. CONCLUSIONS: Our results suggest genistein as a potential alternative to estrogen in the treatment of Alzheimer's disease.
