Therapeutic effect of allogeneic hematopoietic stem cell transplantation on acute myeloid leukemia and influencing factors of survival prognosis
- VernacularTitle:异基因造血干细胞移植对急性髓系白血病的疗效观察及生存预后影响因素分析
- Author:
Ying DONG
1
;
Xiong ZHANG
;
Wei YANG
;
Zan LI
;
Ying LE
;
Maoqun GU
Author Information
- Keywords: allogeneic hematopoietic stem cell transplantation; acute myeloid leukemia; sur-vival prognosis; recurrence; influencing factors
- From: Journal of Clinical Medicine in Practice 2024;28(22):41-45
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the therapeutic effect of allogeneic hematopoietic stem cell transplantation(allo-HSCT)on acute myeloid leukemia(AML)and analyze the influencing factors of survival prognosis.Methods The clinical data of 32 AML patients who underwent allo-HSCT treat-ment were retrospectively analyzed.The hematopoietic reconstitution,occurrence of graft-versus-host disease(GVHD),survival status,recurrence,and transplantation-related mortality(TRM)of pa-tients were observed,and the influencing factors of survival prognosis were analyzed.Results All 32 AML patients who underwent allo-HSCT achieved granulocyte reconstitution,with a time range of 10 to 26 days and a median time of 11.0 days.Granulocyte-macrophage lineage reconstitution was achieved in 30 patients,with a time range of 10 to 54 days and a median time of 13.5 days.Among the 30 evaluable patients,10 developed acute GVHD(with incidence rate of 33.33％)and 10 developed chronic GVHD(incidence rate of 33.33％).Up to May 31,2023,the follow-up time ranged from 2 to 28 months,with a median follow-up time of 14.5 months.Of the 30 patients,28 survived(25 pa-tients were in disease-free survival status),and 2 died.Multivariate Cox regression analysis showed that age＞35 years(P=0.035,HR=2.021)and recurrence after transplantation(P=0.021,HR=2.546)were independent risk factors of patients'survival prognosis.Among 30 patients,5 relapsed,with a time range of 6 to 24 months and a median time of 9.0 months.Of 5 relapsed patients,2 died(non-TRM).Conclusion Allo-HSCT is an effective treatment for AML.Age＞35 years and recur-rence after transplantation are independent risk factors of patients'survival prognosis.
