Effect of intratympanic injection of dexamethasone in the treatment of middle-aged and elderly patients with sudden deafness
- VernacularTitle:地塞米松鼓室内注射治疗中老年突发性耳聋的效果观察
- Author:
Wenjie MIAO
1
;
Chuntao WU
;
Baocai LU
Author Information
- Keywords: dexamethasone; intravenous infusion; intratympanic injection; middle-aged and elderly population; sudden deafness; efficacy; safety
- From: Journal of Clinical Medicine in Practice 2024;28(19):114-117,122
- CountryChina
- Language:Chinese
- Abstract: Objective To compare the efficacy and safety of intravenous infusion and intratym-panic injection of dexamethasone in the treatment of sudden deafness(SD)in middle-aged and elder-ly patients.Methods A total of 115 middle-aged and elderly SD patients in the hospital from July 2018 to November 2023 were randomly divided into group A(n=57)and group B(n=58).Group A received intravenous infusion of dexamethasone,while group B received intratympanic injection of dexamethasone.The symptom improvement time(tinnitus disappearance time,vomiting disappear-ance time,vertigo disappearance time,and hearing recovery time),hearing thresholds(high and low frequencies),sleep quality[the Pittsburgh Sleep Quality Index(PSQI)],vascular endothelial func-tion[nitric oxide(NO),lipid peroxide(LPO)and superoxide dismutase(SOD)],clinical effica-cy,and adverse reactions(transient vertigo,mild ear pain,rash)were compared between the two groups.Results The tinnitus disappearance time,vomiting disappearance time,vertigo disappear-ance time,and hearing recovery time in group B were significantly shorter than those in group A(P＜0.05).The hearing thresholds at high and low frequencies after treatment in both groups were significantly lower than those before treatment,and the hearing thresholds in group B were significant-ly lower than those in group A after treatment(P＜0.05).The PSQI scores after treatment in both groups were significantly lower than those before treatment,and the PSQI score in group B was signifi-cantly lower than that in group A after treatment(P＜0.05).After treatment,NO and SOD in group B were significantly higher than those in group A,while LPO was significantly lower than that in group A(P＜0.05).The total effective rate in the group B was 93.10％,which was significantly higher than 78.95％in the group A(P＜0.05).The incidence of adverse reactions was 12.07％in group B and 10.53％in group A,with no significant between-group difference(P＞0.05).Conclusion Intra-tympanic injection of dexamethasone is more effective than intravenous infusion in the treatment of SD in middle-aged and elderly patients,with faster symptom relief,improved hearing thresholds,better sleep quality,and endothelial function,without increasing adverse reactions,demonstrating high efficacy and safety.
