A Meta-analysis in efficacy and safety of selective posterior rhizotomy for patients with cerebral palsy at different grades of the Gross Motor Function Classification System
- VernacularTitle:选择性脊神经后根切断术对不同粗大运动功能分级系统等级脑性瘫痪患者疗效及安全性的Meta分析
- Author:
Yu JIANG
1
;
Gang LIU
;
Luyao HUO
;
Huizhong BAI
;
Jingpei REN
;
Yi ZHAO
;
Chuanyu HU
;
Lin XU
;
Xiaohong MU
Author Information
- Keywords: cerebral palsy; selective posterior rhizotomy; Gross Motor Function Classifica-tion System; Meta-analysis; self-care ability
- From: Journal of Clinical Medicine in Practice 2024;28(19):60-67
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the differences in efficacy and safety in the treatment of patients with cerebral palsy at different grades of the Gross Motor Function Classification System(GMFCS)by selective posterior rhizotomy(SPR).Methods Relevant literatures on SPR treatment for cerebral palsy were retrieved from Pubmed,Embase,Web of Science,China Biology Medicine disc,China National Knowledge Infrastructure(CNKI),Wanfang Database,and VIP Database.Clinical trials on SPR treatment for cerebral palsy were included for Meta-analysis.At least two re-searchers independently screened the literatures,extracted data,and assessed the quality of the liter-atures.Data analysis was performed by Review Manager 5.4 software.Results A total of 2,726 lit-eratures were retrieved,and 8 literatures were finally included after screening.The results of the Me-ta-analysis showed that the gross motor function and self-care ability of patients with cerebral palsy at all GMFCS grades improved significantly after surgery,and muscle tone decreased significantly after surgery(P＜0.05).In comparison of the improvement in gross motor function before and after SPR,patients with grades Ⅱ and Ⅲ of GMFCS benefited the most,followed by those with grade Ⅰ,and those with grades Ⅳ and Ⅴ benefited less.In terms of improving self-care ability,patients with grade Ⅰbenefited the most,followed by those with grade Ⅲ,and those with grades Ⅱ and Ⅳ benefited less.No significant adverse reactions were reported in previous literatures.Conclusion SPR is a relatively safe and effective treatment option for patients with cerebral palsy.Patients at grades Ⅱand Ⅲ of GMFCS benefit the most from SPR,and patients at grades Ⅳ and V with poor preoperative physical status can also benefit from SPR.
