Impact of Coronavirus Disease 2019 on long-term renal function in patients with chronic kidney disease undergoing no renal replacement therapy
- VernacularTitle:新型冠状病毒感染对未接受肾脏替代治疗的慢性肾脏病患者肾功能的长期影响
- Author:
Qianqian TIAN
1
;
Qiuchan WU
;
Yuanjun FENG
;
Zulong ZHANG
;
Mei LI
;
Xuan ZHANG
;
Moujin XIE
;
Qunchao QING
;
Lei LIU
Author Information
- Keywords: chronic kidney disease; Coronavirus Disease 2019; estimated glomerular filtra-tion rate; renal replacement therapy
- From: Journal of Clinical Medicine in Practice 2024;28(18):86-89,94
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the impact of Coronavirus Disease 2019(COVID-19)on long-term renal function in patients with chronic kidney disease(CKD)who received no renal re-placement therapy.Methods Thirty-nine CKD patients with an estimated glomerular filtration rate(eGFR)＜60 mL/(min·1.73 m2)at the time of COVID-19 diagnosis,admitted to Guizhou Aero-space Hospital from December 2022 to March 2023,were enrolled in the COVID-19 group.Addition-ally,40 CKD patients without COVID-19 from September to December 2021,were included in control group.Changes in eGFR were compared between the two groups,and the temporal trend of eGFR in the COVID-19 group was analyzed using a mixed-effects linear model.Results No statistically sig-nificant differences were observed in eGFR levels at baseline,1-and 3-month of follow-up between the COVID-19 and control groups(P＞0.05).However,at 1 year of follow-up,the eGFR level in the COVID-19 group was significantly lower than that in the control group(P＜0.05).The mixed-effects linear model analysis revealed a decrease in eGFR by 1.84 mL/(min·1.73 m2)within 1 year of COVID-19 onset in the COVID-19 group,which inclined 4.62％from baseline,with the most significant decline(7.45％)observed among diabetic patients.Conclusion Patients with CKD who have not undergone renal replacement therapy experience a substantial decline in eGFR and worsened renal function within 1 year of COVID-19,necessitating close long-term renal function mo-nitoring and timely interventions.
