Research progress on hypoxia-inducible factor 1αin targeted therapy for hepatocellular carcinoma
- VernacularTitle:缺氧诱导因子1α在肝细胞癌靶点治疗中的研究进展
- Author:
Liheng HUANG
1
,
2
;
Hongsheng LIN
;
Zengfu DENG
;
Li YANG
;
Mingfen LI
Author Information
- Keywords: hypoxia-inducible factor; hepatocellular carcinoma; hypoxia-inducible factor 1 α
- From: Journal of Clinical Medicine in Practice 2024;28(17):127-130
- CountryChina
- Language:Chinese
- Abstract: Novel therapeutic approaches targeting key genes and regulatory molecules of hepato-cellular carcinoma(HCC)have gradually been carried out in clinical practice.Hypoxia-inducible factor(HIF),as a critical factor for hepatocellular carcinoma cells to adapt to the hypoxic microenvi-ronment,mediates changes in the transcription of many genes.HIF has a wide range of target genes and can promote metabolic reprogramming,angiogenesis,invasion and metastasis,and immune es-cape of cancer cells by regulating various signaling pathways.Hypoxia-inducible factor 1α(HIF-1α),as the main member of the HIF family,can provide new ideas and insights for exploring potential tar-gets for HCC treatment.
