Effect of nicorandil combined with rosuvastatin calcium in treatment of patients with slow coronary flow
- VernacularTitle:尼可地尔联合瑞舒伐他汀钙治疗冠状动脉慢血流患者的效果观察
- Author:
Zhiqin FANG
1
;
Huiqing LIANG
;
Pengxiang ZHANG
;
Kun ZHAO
;
Yiping MA
;
Yaling WANG
;
Fangjiang LI
;
Jun LI
;
Pingping LI
Author Information
- Keywords: nicorandil; rosuvastatin calcium; slow coronary flow; monocyte-to-high density lipoprotein cholesterol ratio; systemic immune-inflammation index; left ventricular function; three-dimensional speckle tracking echocardiography
- From: Journal of Clinical Medicine in Practice 2024;28(15):70-75
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effects of nicorandil combined with rosuvastatin calci-um on monocyte-to-high density lipoprotein cholesterol ratio(MHR),systemic immune-inflammation index(SII),and cardiac function in patients with coronary slow flow(CSF).Methods A group case-control study was used to select 240 patients with CSF confirmed by coronary angiography,and they were randomly divided into observation group and control group,with 120 patients in each group.On the basis of conventional drug treatment,the control group was treated with rosuvastatin calcium,while the observation group was treated with nicorandil combined with rosuvastatin calcium for 6 months.Clinical efficacy,inflammatory markers[high-sensitivity C-reactive protein(hs-CRP),MHR,SII],corrected TIMI frame count(CTFC)of major coronary branches[left anterior descend-ing branch(LAD),left circumflex branch(LCX),right coronary artery(RCA)],cardiac function indicators[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),global longitudinal strain(GLS)],and the occurrence of major adverse cardiovascular events(MACE)were compared between the two groups.Results The total effective rate in the observation group-was significantly higher than that in the control group(95.00％versus 80.00％,P＜0.05).After treatment,the duration,severity,andfrequency of angina pectoris attacks were reduced or shortened in both groups,with more changes observed in the observation group(P＜0.05).Serum levels of hs-CRP,MHR,and SII were lower in both groups after 6 months of treatment,and the observation group with significantly was lower compared to the control group(P＜0.05).CTFC values of LAD,LCX,and RCA were also lower in both groups after 6 months,with the observation group showing significantly lower values(P＜0.05).The absolute values of LVEF and GLS increased in both groups after 6 months of treatment,and the observation group was higher than the control group(P＜0.05).However,no significant difference was observed in LVEDD and occurrence of MACE between the two groups(P＞0.05).Conclusion The application of nicorandil combined with ro-suvastatin calcium in the treatment of CSF patients can significantly improve the overall treatment ef-ficacy,reduce hs-CRP,MHR,and SII levels,enhance cardiac function indicators such as LVEF,LVEDD,and GLS,and effectively alleviate the severity of angina pectoris attacks.
