Predictive value of white blood cell-to-hematocrit ratio for in-hospital major adverse cardiovascular events after reperfusion therapy in patients with acute ST-segment elevation myocardial infarction
- VernacularTitle:白细胞与红细胞比容比值对急性ST段抬高型心肌梗死再灌注治疗后院内主要不良心血管事件的预测价值
- Author:
Linjuan JI
1
;
Xin TIAN
;
Tao RUI
;
Yongwei YAO
Author Information
- Keywords: white blood cell; hematocrit; acute ST-segment elevation myocardial infarction; percutaneous coronary intervention; major adverse cardiovascular events
- From: Journal of Clinical Medicine in Practice 2024;28(15):14-18,25
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the predictive value of white blood cell-to-hematocrit ratio(WBCHR)for in-hospital major adverse cardiovascular events(MACE)after reperfusion therapy in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A case-control study was conducted to retrospectively select 319 patients with first-time diagnosis of STEMI who un-derwent percutaneous coronary intervention(PCI).Patients were divided into MACE group(69 ca-ses)and non-MACE group(250 cases)based on the occurrence of MACE during hospitalization.Clinical data,including general information,laboratory test indicators,echocardiography,and coro-nary angiography results,were compared between the two groups.Univariate and multivariate Logistic regression analyses were performed to explore the risk factors for in-hospital MACE after reperfusion therapy in STEMI patients.Receiver operating characteristic(ROC)curve analysis was conducted to evaluate the predictive value of WBCHR for in-hospital MACE after reperfusion therapy in STEMI patients.Results The levels of fasting blood glucose,uric acid,creatinine,white blood cell count,neutrophil count,high-sensitivity C-reactive protein(hs-CRP),D-dimer,and WBCHR were significantly higher in the MACE group than in the non-MACE group,while red blood cell count,hemoglobin,hematocrit,and left ventricular ejection fraction were lower(P＜0.05).No significant differences were observed in age,gender,smoking history,hypertension history,diabetes history,door-to-wire(D2W)time,total cholesterol,triglycerides,and the number of diseased vessels be-tween the two groups(P＞0.05).Multivariate Logistic regression analysis revealed that elevated u-ric acid levels(OR=1.005;95％CI,1.002 to 1.009;P=0.004),decreased hemoglobin concen-tration(OR=0.964;95％CI,0.941 to 0.988;P=0.003),increased hs-CRP levels(OR=1.032;95％CI,1.009 to 1.056;P=0.007),and increased WBCHR(OR=1.455;95％CI,1.295 to 1.635;P＜0.001)were independent risk factors for in-hospital MACE after reperfusion therapy in STEMI patients.ROC curve analysis showed that the area under the curve of WBCHR for predicting in-hospital MACE after reperfusion therapy in STEMI patients was 0.855(95％CI,0.796 to 0.914,P＜0.001),with a sensitivity of 63.8％and a specificity of 99.6％.Conclusion WBCHR is an independent influencing factors of in-hospital MACE after reperfusion therapy in STEMI patients and has a high predictive value for in-hospital MACE in these patients.
