Relationship between heart rate variability and baseline clinical characteristics in super-aged patients with persistent atrial fibrillation
- VernacularTitle:超高龄持续性心房颤动患者心率变异性与基础临床特征的关系分析
- Author:
Xiaoyan WANG
1
;
Jian XU
;
Jin QIAN
;
Surong JIANG
;
Sen WANG
Author Information
- Keywords: super-age; atrial fibrillation; heart rate variability; hypertension; β-blockers; dabigatran
- From: Journal of Clinical Medicine in Practice 2024;28(9):67-72
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationship between heart rate variability(HRV)and baseline clinical characteristics in super-aged(≥80 years old)patients with persistent atrial fibrilla-tion(AF).Methods A total of 108 super-aged patients with persistent AF were included in AF group,and 127 super-aged patients with sinus rhythm were included in control group.24-hour ambu-latory electrocardiogram monitoring was conducted to compare heart rate and HRV time-domain indi-cators[standard deviation of normal RR intervals(SDNN),standard deviation of the average of nor-mal to normal intervals(SDANN)every 5 minutes throughout the recording,mean of the sum of the squares of differences between adjacent N-N intervals(RMSSD),average value of standard deviation of 5-minute NN intervals throughout the recording(SDNN index),heart rate variability(HRV)in-dex,and percentage of NN intervals with differences greater than 50 ms accounting for the total num-ber of NN intervals(PNN50)].Clinical characteristics of AF patients were collected,and multiple linear regression analysis was used to explore the correlation between HRV time-domain indicators and heart rate and baseline clinical characteristics.Results SDNN,RMSSD,HRV index,PNN50,and SDNN index were higher in the AF group than in the control group(P＜0.01).Multiple linear regression analysis showed that increased SDNN was significantly associated with hypertension(P=0.001),use of β-blockers(P=0.003),and slow heart rate(P＜0.001).Increased RMSSD wassignificantly associated with hypertension(P=0.040),use of β-blockers(P=0.002),and slow heart rate(P＜0.001).Increased HRV index was significantly associated with heart failure(P=0.003)and slow heart rate(P＜0.001).Increased PNN50 was significantly associated with slow heart rate(P=0.004).Increased SDNN index was significantly associated with the use of β-blockers(P=0.002)and slow heart rate(P＜0.001).Increased SDANN was significantly associated with hy-pertension(P=0.006),slow heart rate(P＜0.001),and use of dabigatran(P=0.021).Con-clusion There is a correlation between HRV and baseline clinical characteristics in super-aged pa-tients with persistent AF,which may be due to the activity status of the autonomic nervous system.
