Relationships of retinoid X receptor alpha and nuclear receptor interaction protein 1 expressions with prognosis in colorectal cancer
- VernacularTitle:结直肠癌组织中核受体视黄酸X受体a及核受体相互作用蛋白1的表达与预后的关系
- Author:
Yihua CHEN
1
;
Yan LUO
;
Qiang TIAN
;
Dongmei ZENG
;
Lei XU
Author Information
- Keywords: colorectal cancer; retinoid X receptor alpha; nuclear receptor interaction protein 1; clinicopathology; prognosis
- From: Journal of Clinical Medicine in Practice 2024;28(7):36-40
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the relationships of the expression of retinoid X receptor alpha(RXRA)and nuclear receptor interaction protein 1(NRIP1)in colorectal cancer tissues with the fea-tures of clinical pathology and prognosis.Methods A total of 106 specimens from colorectal cancer tissues of patients during surgery were included in colorectal cancer group(n=106),and corre-sponding paracancer tissue specimens were included in paracancer group(n=106).The expressions of RXRA and NRIP1 in colorectal cancer tissues were detected by immunohistochemistry.Multivariate Cox regression analysis was used to investigate th4e effects of RXRA and NRIP1 expressions on the prognosis of patients with colorectal cancer.Results The positive expression rates of RXRA and NRIP1 in colorectal cancer group were 66.04％,69.81％,which were significantly higher than 33.96％and 30.19％in the para-cancer group(P＜0.05).The positive expression rates of RXRA and NRIP1 in patients with pathological stage Ⅲ,low differentiation,serous infiltration and lymph node metastasis were higher than those in patients with pathological stage Ⅱ,medium and high differ-entiation,no serous infiltration and lymph node metastasis(P＜0.05).The 3-year overall survival rates of patients with pathological stage Ⅱ,low differentiation,no serous infiltration,no lymph node metastasis,negative RXRA and NRIP1 were higher than those of patients with pathological stage Ⅲ,medium and high differentiation,serous infiltration,lymph node metastasis,positive RXRA and NRIP1(P＜0.05).Multivariate Cox regression analysis showed serous membrane infiltration(HR=2.687;95％CI,1.531 to 3.156),positive RXRA(HR=3.743;95％CI,2.217 to 5.992),positive NRIP1(HR=2.641;95％CI,1.124 to 4.757)were influencing factors for prognosis in patients with colorectal cancer(P＜0.05).Conclusion RXRA and NRIP1 are highly expressed in color-ectal cancer,which are closely related to pathological stage,differentiation degree and metastasis,which can be used as biomarkers to assist in evaluating the prognosis of patients.
