Research progress of microinflammatory state and disease severity in patients with chronic obstructive pulmonary disease
- VernacularTitle:微炎症状态与慢性阻塞性肺疾病患者病情严重程度的研究进展
- Author:
Ouli CHEN
1
;
Zhenli WANG
Author Information
- Keywords: chronic obstructive pulmonary disease; microinflammatory state; disease severity; C-reactive protein; tumor necrosis factor-α
- From: Journal of Clinical Medicine in Practice 2024;28(6):139-142,148
- CountryChina
- Language:Chinese
- Abstract: Chronic obstructive pulmonary disease(COPD)is a common respiratory system dis-ease,with high incidence rate and mortality.So far,the pathogenesis of COPD has not been clearly determined.Microinflammatory state refers to the growth and reproduction of certain pathogens in the body due to bacteria,viruses and fungi infections,which causes inflammatory response of local tissues and the whole body,it is manifested by a slight and continuous increase of inflammatory marker pro-teins and inflammatory cytokines in systemic circulation.This article reviewed the literature on micro-inflammatory state and COPD.It is concluded that microinflammatory state will lead to the imbalance of proinflammatory and anti-inflammatory mechanisms,which can cause ischemic and hypoxic destruc-tion and injury of lung tissue cells,and further aggravate lung injury.The common inflammatory fac-tors such as C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and interleukin(IL)in microinflammatory state are closely related to the severity of COPD,which may promote disease pro-gression,continuously affect lung function,arterial blood gas and nutritional status of patients.
