Analysis of clinical value of serum inflammatory factors combined with pulmonary function index in identification of severe mycoplasma pneumonia in children
- VernacularTitle:血清炎症因子联合肺功能指标识别患儿重症支原体肺炎的临床价值分析
- Author:
Jinying LU
1
;
Taotao CHANG
;
Jingjing ZHANG
;
Lijuan LIU
;
Ping YAN
;
Zhanru YIN
Author Information
- Keywords: severe mycoplasma pneumonia; interleukin-6; interleukin-8; lung function; correlation; diagnostic value
- From: Journal of Clinical Medicine in Practice 2024;28(6):65-68,73
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the clinical value of serum interleukin-6(IL-6)and inter-leukin-8(IL-8)levels in combination with pulmonary function indicators in identifying severe Myco-plasma pneumoniae pneumonia(MPP)in children.Methods A total of 102 children with severe MPP were selected as the study subjects(severe group),and another 102 children with mild MPP treated during the same period were selected as the mild group.The serum levels of IL-6,IL-8 as well as forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1 percent-age of predicted(FEV1％pred)and the ratio of FEV1 to FVC at the time of admission of children in each group were compared.Results The serum levels of IL-6 and IL-8 in the severe group were sig-nificantly higher than those in the mild group,while the FVC,FEV,％pred,and FEV1/FVC％were significantly lower than those in the mild group(P＜0.05).The serum levels of IL-6 and IL-8 were negatively correlated with FVC,FEV1％pred and FEV1/FVC％(P＜0.05).The area under the curve(AUC)for assessing the severity of MPP for IL-6,IL-8,FVC,FEV1％pred and FEV1/FVC％was 0.894(0.849 to 0.939),0.842(0.787 to 0.897),0.896(0.851 to 0.942),0.787(0.725 to 0.849)and 0.744(0.676 to 0.812),respectively.The AUC for the combined assessment of the above five parameters was 0.985(0.973 to 0.997).Conclusion Serum IL-6,IL-8 and pulmonary function indicators can reflect the severity of MPP in children.Their combined detection can be used to differentiate between mild and severe MPP in children early and timely.
