Research progress on predictive value of immune cells in chemoradiotherapy for rectal cancer
- VernacularTitle:免疫细胞在直肠癌放化疗中预测价值的研究进展
- Author:
Hong CHEN
1
;
Yingna BAO
;
Jianguo ZHAO
Author Information
- Keywords: rectal cancer; neoadjuvant chemoradiotherapy; immune cells; biomarkers; tumor microenvironment
- From: Journal of Clinical Medicine in Practice 2024;28(1):133-138
- CountryChina
- Language:Chinese
- Abstract: Neoadjuvant chemoradiotherapy(NCRT)is the standard therapeutic strategy for lo-cally advanced rectal cancer(LARC).Due to the different responses of patients to NCRT,the clini-cal prognosis of patients varies greatly.Therefore,it is important to establish sensitive biomarkers to predict the response of patients to treatments before NCRT.Immune cells in the tumor microenviron-ment(TME)were closely related to the efficacy of NCRT in patients with LARC.This paper re-viewed the research progress on the relationships of cytotoxic T cells,programmed death-ligand 1(PD-L1),tumor-associated macrophages(TAMs),regulatory T cells(Treg)and neutrophil to lym-phocyte ratio(NLR)with chemoradiotherapy sensitivity in rectal cancer,illustrated the potential and limitations of these immune cells in predicting chemoradiotherapy response in rectal cancer,and pro-vided a feasible direction for future researches.
