Application effect of protease combined with quadruple therapy in the remedial treatment of Helicobacter pylori eradication failure
- VernacularTitle:链霉蛋白酶联合四联方案在根除幽门螺杆菌失败补救治疗中的应用效果
- Author:
Hao DONG
1
;
Xiaorui DING
;
Yanqiu YUE
Author Information
- Keywords: pronase; Helicobacter pylori; quadruple therapy; digestive system; eradication rate
- From: Journal of Clinical Medicine in Practice 2024;28(1):86-89
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the application effect of protease combined with quadruple therapy in the remedial treatment of Helicobacter pylori(Hp)eradication failure.Methods A total of 100 patients with Hp infection who failed in initial treatment were selected as the study objects,and were divided into control group(50 cases)and observation group(50 cases),and two groups re-ceived a course of treatment for 14 days.The control group was given esomeprazole enteric-coated tab-lets,amoxicillin capsules,furazolidone tablets and colloidal bismuth pectin capsules.The observation group was given streptomycin granule and sodium bicarbonate powder on the basis of the control group.Hp eradication rates were calculated for intention to treat(ITT)analysis and per protocol(PP)analysis.The symptoms and adverse drug reactions before and after treatment were recorded in two groups.Results In the control group,18 cases were successfully eradicated,the eradication rate by ITT analysis was 36％,and the eradication rate by PP analysis was 36％.In the observation group,37 patients had negative 14C breath test results,with an eradication rate of74％by ITT analy-sis and 74％by TT analysis.There was statistical significance in the eradication rate between the two groups(P＜0.05).There was no significant difference in compliance between the two groups(P＞0.05).The improvement of abdominal pain symptoms before and after eradication was statistically significant between the two groups(P＜0.05).There was no significant difference in adverse reac-tions between the two groups(P＞0.05).Conclusion The remedial treatment regimen of strepto-mycin combined with quadruple therapy can improve the eradication rate of Hp infection patients whose initial eradication failed.
