Effect of Saccharomyces boulardii combined with ursodeoxycholic acid in treating rectal ulcerative colitis and its influence on intestinal mucosal barrier function
- VernacularTitle:布拉氏酵母菌联合熊去氧胆酸治疗直肠型溃疡性结肠炎的疗效及对肠黏膜屏障功能的影响
- Author:
Xuan HAN
1
;
Xu HAN
;
Yanru CHENG
;
Jinyu DAI
Author Information
- Keywords: Saccharomyces boulardii; ursodeoxycholic acid; rectal ulcerative colitis; intesti-nal mucosal barrier function; inflammatory factors; adverse reactions
- From: Journal of Clinical Medicine in Practice 2024;28(1):73-77
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the efficacy of Saccharomyces boulardii combined with ur-sodeoxycholic acid in the treating rectal ulcerative colitis(UC)and its influence on intestinal mucosal barrier function.Methods A total of 88 patients with rectal UC were randomly divided into observa-tion group and control group,with 44 cases in each group.The scores of main symptoms(abdominal pain,diarrhea,purulent stool),score of the Inflammatory Bowel Disease Questionnaire(IBDQ),lev-els of inflammatory factor indicators[interleukin-6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]and levels of intestinal mucosal barrier function indicators[the ratio of urinary lac-tolic acid to mannitol(L/M),serum D-lactic acid(D-LA),serum diamine oxidase(DAO),and ser-um lipopolysaccharide(LPS)]were compared between the two groups before and after treatment.The incidence of adverse reactions were compared between two groups.Results After treatment,the scores of abdominal pain,diarrhea and purulent stool in both groups were significantly lower than those before treatment,while the IBDQ score was significantly higher than that before treatment,and the scores of abdominal pain,diarrhea and purulent stool in the observation group were significantly lower than those in the control group,while the IBDQ score was significantly higher than that in the control group(P＜0.05).After treatment,the levels of serum D-LA,DAO,LPS and urinary L/M in both groups reduced significantly,and the levels of these indicators in the observation group were signifi-cantly lower than those in the control group(P＜0.05).After treatment,the levels of serum IL-6,TNF-α and IL-1β in both groups reduced significantly,and the levels of these indicators in the observation group were significantly lower than those in the control group(P＜0.05).The total ef-fective rate inthe observation group was 86.36％,which was significantly higher than 68.18％in the control group(P＜0.05).There were no significant differences in incidence rates of adverse re-actions such as lower abdominal pain,allergies and refractory constipation between two groups(P＞0.05).Conclusion Saccharomyces boulardii combined with ursodeoxycholic acid is effective in the treatment of patients with rectal UC,which can effectively improve symptoms such as abdominal pain,diarrhea and purulent stool,inhibit the inflammatory response of the body,and alleviate dam-age to the intestinal mucosal barrier.
