Application of non-invasive mechanical ventilation with different oxygen concentrations in patients with acute exacerbation of chronic obstructive pulmonary disease and type Ⅱ respiratory failure
- VernacularTitle:不同氧浓度无创机械通气在慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭患者中的应用
- Author:
Qian MIN
1
;
Tianhong HE
;
Li YANG
;
Mei WANG
Author Information
- Keywords: acute exacerbation of chronic obstructive pulmonary disease; respiratory failure; non-invasive mechanical ventilation; fraction of inhaled oxygen; blood gas parameter; serum high mobility group box-1; interleukin-27
- From: Journal of Clinical Medicine in Practice 2023;27(24):59-62,67
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the influence of different fractions of inspired oxygen used in non-invasive mechanical ventilation on blood gas parameters and serum high mobility group box-1(HMGB1)and interleukin-27(IL-27)levels in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and type Ⅱ respiratory failure.Methods A total of 152 patients with AECOPD and type Ⅱ respiratory failure were selected as the subjects of the study and divided into group A(n=76)and group B(n=76)using a random number table method.The fraction of in-spired oxygen used in non-invasive mechanical ventilation in the group A was 45％,while was 60％in the group B.The changes in blood gas parameters,serum HMGB1 and IL-27 levels at different time points were compared between the groups;the occurrence of complications during treatment was recor-ded.Results After 7 days of treatment,the arterial oxygen partial pressure[pa(O2)]and pH levels in the group A were significantly higher than those in the group B,while the arterial carbon dioxide partial pressure[pa(CO2)]level was significantly lower than that in the group B(P＜0.05).After 1 day and 7 days of treatment,the serum HMGB1 and IL-27 levels in the group A were significantly lower than those in the group B(P＜0.05).During the treatment period,there was no significant difference in the overall incidence of complications between the two groups(P＞0.05).Conclusion Compared with 60％inhaled oxygen concentration,AECOPD patients with type Ⅱ respiratory failure receiving non-invasive mechanical ventilation with an inhaled oxygen concentration of 45％have better clinical outcomes.The patients'blood gas indicators,serum HMGB1 and IL-27 levels are significantly im-proved,and the treatment is relatively safe.
