Effects of chloroquine drugs on ionic channels of myocardial cells
10.7619/jcmp.20230562
- VernacularTitle:氯喹类药物对心肌细胞离子通道的影响
- Author:
Xinli LIU
1
;
Hao LIANG
;
Zhengxin XU
Author Information
1. 扬州大学医学院,江苏扬州,225000
- Keywords:
chloroquine;
cardiotoxin;
arrhythmia;
ion channels
- From:
Journal of Clinical Medicine in Practice
2023;27(23):135-138,148
- CountryChina
- Language:Chinese
-
Abstract:
Chloroquine has played a pivotal role in the treatment of malaria.Recently,with the development of clinical application,they are increasingly recognized for their effectiveness in other as-pects,such as anti-inflammation,immunosuppression,anti-amoebic effects and so on.In the outbreak of the new coronavirus infection,chloroquine and its derivative hydroxychloroquine swiftly included in the treatment of infected patients in many countries.However,several studies have shown these drugs have some detrimental influence,especially in cardiac arrhythmia(prolonged the QT interval and in-creased risk of torsional ventricular tachycardia).Thus,we should pay attention to both their benefi-cial effects and potential adverse manifestation.In order to regulate the use of drugs and guide the clin-ic,this paper reviewed the electrophysiological basis and clinical characteristics of cardiac adverse re-actions of these drugs from the perspective of ion channels.
