Impact of ABO blood group on the effect of dabigatran etexilate in the treatment of non-valvular atrial fibrillation
- VernacularTitle:ABO血型对达比加群酯治疗非瓣膜性房颤效果的影响
- Author:
Chenchen QIAO
1
;
Yunlong LIANG
Author Information
- Keywords: atrial fibrillation; dabigatran etexilate; ABO blood type; coagulation factor; pro-tein C activity; von Willebrand factor
- From: Journal of Clinical Medicine in Practice 2023;27(23):63-67
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the changes of coagulation indexes in patients of non-valvular atrial fibrillation with different ABO blood types before and after treatment with the new oral anticoag-ulant dabigatran etexilate.Methods A total of 100 patients with non-valvular atrial fibrillation were selected as research subjects,and they were divided into type O group(n=50)and non-type 0 group(n=50)according to blood types,and dabigatran etexilate capsules were given to both groups.The coagulation function indexes of the two groups after 3 months were compared.Results Before treatment,there were significant differences in Von Willebrand factor(vWF)and protein C activities between two groups(P＜0.05).After treatment,the activities of vWF and protein C showed signifi-cant differences between two groups(P＜0.05).Before treatment,there was no significant differ-ence in activated partial thromboplastin time(APTT)between the two groups(P＞0.05),but there was a significant difference in APTT between the two groups after treatment(P＜0.05).There were no significant between-group differences in plasma prothrombin time(PT),thrombin time(TT),in-ternational normalized ratio(INR)and coagulation factor Ⅷ before and after treatment(P＞0.05).There were significant differences in all coagulation related indexes between the two groups after treat-ment compared with treatment before(P＜0.05).Conclusion Patients with type O blood are more likely to alert to occurrence of bleeding events when treated with dabigatran etexilate,and can be pre-dicted by APTT and protein C activity to some extent.
