Retrospective Analysis for Complications of the Central Venous Catheter in Patients with Cancer at a Single Center in Korea.
- Author:
Eun Jung KIM
1
;
Hyun Jung KIM
;
Han Jo KIM
;
Kyoung Ha KIM
;
Se Hyung KIM
;
Sang Cheol LEE
;
Sang Byung BAE
;
Chan Kyu KIM
;
Nam Su LEE
;
Kyu Taek LEE
;
Sung Kyu PARK
;
Jong Ho WON
;
Hee Sook PARK
;
Dae Sik HONG
Author Information
1. Division of Hematology and Oncology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea. dshong@schbc.ac.kr
- Publication Type:Original Article
- Keywords:
Catheterization;
Central venous;
Hematologic neoplasms/complications;
Neoplasms
- MeSH:
Catheterization;
Catheterization, Central Venous;
Catheters;
Central Venous Catheters;
Humans;
Kaplan-Meier Estimate;
Korea;
Male;
Multivariate Analysis;
Parenteral Nutrition;
Retrospective Studies;
Thrombosis
- From:Korean Journal of Hospice and Palliative Care
2010;13(1):24-31
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: A central venous catheterization (CVC) is frequently used for delivering anti-cancer chemotherapeutic agents, blood products, parenteral nutrition, and other intravenous therapy in patients with cancer. Major complications of CVC use are thrombosis, infection, and mechanical complications. The aim of this study was to evaluate the frequency of CVC complications and related factors. METHODS: The records of cancer patients who received a CVC at our university hospital from March 2001 to October 2006 were retrospectively investigated. Chi square test was used to determine whether there was a related factor for thrombosis or infection, and Kaplan-Meier analysis for univariate analysis, or Cox-regression analysis for multivariate analysis was used for catheter life span. RESULTS: Three hundred and ten CVCs (235 nontunneled, 75 tunneled) were inserted in 310 patients (157 males, 153 females). Among them, 104 had hematologic cancers and 206 had solid cancers. The mean age of the patients was 52 years (range, 19~82 years). CVC complications occurred in 60 cases (19%). CVC-related thrombosis occurred frequently in patients with infection (P=0.003), whereas diagnosis, catheter type, transfusion, and TPN history did not affect infection or thrombosis. The mean duration of the catheter was 102 days (range, 2~1,330 days), and the duration was prolonged in patients with tunneled catheters (P=0.000), or without transfusion through CVC (P=0.030). CONCLUSION: The major complications for long-term use of a CVC were infectionand thrombosis. Tunneled catheter was effective tool for long term use, especially in cases without transfusion through CVC. The studies on the prevention or treatment ofthrombosis and infection are, therefore, warranted by using CVC for an extended period of time.
