Effect of dexmedetomidine combined with fentanil on postoperative sleep quality and cognitive function in elderly patients with patient-controlled intravenous analgesia
10.7619/jcmp.201908008
- VernacularTitle:右美托咪定复合芬太尼静脉自控镇痛对老年患者术后睡眠及认知功能的影响
- Author:
Xiaoli WU
1
;
Xiangnan LI
;
Ruyi SHENG
;
Jing QIAN
;
Conghu YUAN
Author Information
1. 江苏省盐城市第三人民医院 麻醉科
- Keywords:
dexmedetomidine;
fentanil;
elderly patients;
sleep;
cognitive function
- From:
Journal of Clinical Medicine in Practice
2019;23(8):32-34,38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexmedetomidine combined with fentanil on postoperative sleep quality and cognitive function in elderly patients with patient-controlled intravenous analgesia (PCIA). Methods Forty elderly patients underwent thoracic surgery were randomly divided into control group (fentanil group, n = 20) and experimental group C (fentanil plus dexmedetomidine group, n = 20), The control group was mixed 15 μg/kg fentanil and 5 mg tropisetron into100 mL of normal saline in patient-controlled intravenous analgesia pump, and experimental group contained 15 μg/kg fentanil, 1. 0 μg/kg dexmedetomidine and 5 mg tropisetron in 100 mL of normal saline. The pump was withdrawn after 48 h. The total steep time, sleep quality were recorded at 1 d before surgery and on the day of surgery, and at 3 d after surgery. The Mini-Mental Status Examination (MMSE) were recorded at 1 d before surgery and 1, 3, 7 d after surgery, and the incidence of postoperative cognitive dysfunction was observed. Results Compared with control group, the sleep time of experimental group on the surgery day and at 2 d after surgery was longer (P ＜ 0. 05); the sleep quality were significantly higher (P ＜ 0. 05); the MMSE scores of experimental group on the first and third postoperative day were higher (P ＜ 0. 05), and the incidence of POPD was lower than that in the control group (P ＜ 0. 05). Conclusion Dexmedetomidine combined with fentanil administered for postoperative analgesia in elderly patients shows better efficacy in improvement of sleep status, and improve the postoperative cognitive function.
