Efficacy and safety of progressive dose-adding of alprazolam midazolam in the treatment of chronic tinnitus
- VernacularTitle:阿普唑仑渐进式加量治疗慢性耳鸣的疗效及安全性
- Author:
Shengpeng CHEN
1
;
Qiong JIANG
Author Information
- Keywords: chronic tinnitus; alprazolam; progressive incremental dosage therapy; efficacy; safety
- From: Journal of Clinical Medicine in Practice 2018;22(11):123-125
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the efficacy and safety of progressive dose-adding of alprazolam midazolam in the treatment of chronic tinnitus.Methods A total of 80 chronic tinnitus patients were divided into observation group and control group,with 40 cases in each group.The control group was treated with conventional nutritional nerve and improved circulation treatment,while the observation group was additionally treated with alprazolam progressive incremental treatment.The therapeutic effects of the two groups were observed.The THI score,VAS score,tinnitus loudness and adverse reactions after treatment were observed.Results The total effective rate of the observation group was significantly higher than that of the control group (80％ vs.57.5％,P ＜ 0.05).There were no significant differences in the THI score,VAS score and tinnitus loudness between the two groups before treatment (P ＞ 0.05).After treatment,the THI score,VAS score and tinnitus loudness of the two groups were lower than treatment before (P ＜ 0.05),and the observation group was lower than the control group (P ＜ 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05).Conclusion Application of progressive incremental alprazolam therapy for patients with chronic tinnitus has prominent efficacy and higher safety.
