Effect of CT-guided radiofrequency ablation combined with EGFR-TKI targeted treatment on immune function of advanced non-small cell lung cancer and its therapeutic efficacy
10.7619/jcmp.201811013
- VernacularTitle:CT引导下射频消融联合EGFR-TKI靶向治疗中晚期非小细胞肺癌的效果及对免疫功能的影响
- Author:
Shanling LI
1
;
Jie WANG
;
Sufang CHEN
;
Zhenxing WANG
Author Information
1. 解放军第371中心医院肿瘤科
- Keywords:
non-small cell lung cancer;
targeted therapy;
radiofrequency ablation;
immune function
- From:
Journal of Clinical Medicine in Practice
2018;22(11):47-50,54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of CT-guided radiofrequency ablation combined with EGFR-TKI targeted therapy on the treatment of advanced non-small cell lung cancer (NSCLC) and its influence on immune function.Methods A total of 108 middle and late NSCLC patients who were treated in our hospital were be chosen as study objects.A total of 53 patients undergoing radiofrequency ablation combined with GP therapy were selected as control group,while 55 patients undergoing radiofrequency ablation combined with EGFR-TKI targeted therapy were selected as observation group.The immune function index and life quality index of the two groups were compared.Results After treatment,the levels of CD3 +,CD4 + and CD4 +/CD8 + were increased and CD8 + level was decreased in the two groups,and were significantly higher,and lower,respectively,in observation group than the control group (P ＜ 0.05).After treatment,the indicators of IgG,IgM and IgA in the observation group were increased,and the IgG,IgM and IgA in the control group were decreased(P ＜ 0.05).Physical,emotional,cognitive roles,social function and other indicators of two groups were significantly increased,and the observation group was significantly higher than the control group (P ＜ 0.05).Complications such as Nausea and vomiting,constipation,diarrhea,fatigue,sleep disorder,pain of two groups were decreased significantly,and the observation group was significantly lower than the control group (P ＜ 0.0 5).The total effective rate of clinical treatment in the observation group was 95.45％,which was significantly higher than 45.28％ of the control group (P ＜ 0.05).The 1,2-year survival rates after treatment in the observation group were higher than that in the control group,but there was no statistical difference in two groups (P ＞ 0.05).Conclusion CT-guided radiofrequency ablation combined with EGFR-TKI targeted therapy can significantly improve clinical therapeutic effect,improve immune function and quality of life in patients with advanced NSCLC.
