Effect of short-term glucocorticoid inhalation on related indexes of patients with eosinophilic sinusitis and nasal polyps
10.7619/jcmp.201809024
- VernacularTitle:糖皮质激素短疗程雾化吸入对嗜酸粒细胞性鼻窦炎伴鼻息肉患者相关指标的影响
- Author:
Changping KE
1
Author Information
1. 湖北省荆州市第五人民医院五官科
- Keywords:
glucocorticoid;
inhalation;
eosinophile granulocyte;
chronic sinusitis;
nasal polyps
- From:
Journal of Clinical Medicine in Practice
2018;22(9):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of short-term inhalation of glucocorticoid (GC) on nasal symptoms and signs,EOS count and adrenocortical function in patients with eosinophilic sinusitis and nasal polyps.Methods Totally 80 patients with eosinophilic chronic sinusitis and nasal polyps were randomly divided into control group treated with glucocorticoid by nasal spray and observation group treated with glucocorticoid by inhalation.Short-term efficacy,the VAS score of nasal symptoms,the Lund-Kennedy score by endoscope,the level of EOS count and serum cortisol concentration before and after treatment and the recurrence rate were compared.Results The excellent rate and total effective rate of observation group were significantly higher than control group (P ＜ 0.05).The VAS score of nasal symptom and Lund-Kennedy score by endoscope in observation group after treatment were significantly lower than control group and before treatment (P ＜ 0.05).The recurrence rate at 3,6 months of follow-up in observation group were significantly lower than control group (P ＜0.05).The levels of EOS count of observation group after treatment were significantly lower than control group and before treatment (P ＜ 0.05).There was no significant difference in the level of serum cortisol concentration before and after treatment between two groups (P ＞ 0.05).Conclusion Short-term inhalation of glucocorticoid is effective in the treatment of patients with eosinophilic chronic sinusitis and nasal polyps,which can efficiently relieve nasal symptoms,inhibit the aggregation of eosinophils,reduce the long-term recurrence risk and has no significant effect on the adrenocortical function.
