Correlation between serum calcium, vitamin D levels and bone metastasis of prostate cancer
10.7619/jcmp.201809012
- VernacularTitle:血钙与维生素D水平与前列腺癌骨转移的相关性研究
- Author:
Xiaoxi WANG
1
;
Xiaofeng TAO
;
Wei LIU
;
Jianqing DONG
;
Huijing LIU
Author Information
1. 河北省唐山市人民医院骨软科
- Keywords:
vitamin D;
blood calcium;
prostate cancer;
bone metastases
- From:
Journal of Clinical Medicine in Practice
2018;22(9):48-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the changes of 25-hydroxy vitamin D (25-OH-D) and blood calcium concentrations in the serum of prostate cancer (Pca) patients with bone metastases,and to analyze the correlation between bone calcium metabolism and bone metastasis of prostate cancer.Methods The 35 untreated prostate cancer patients without bone metastases,30 patients with bone metastasis of prostate cancer,and 30 healthy controls were selected,and fluorescent immune chromatography was used to determine the content of 25-OH-D,the Azo arsenic method was used to detect the blood calcium level,and ROC curve was used to analyze the value of two indexes in diagnosing prostate cancer bone metastases.Results The blood calcium content in bone metastasis of prostate cancer group was significantly higher than the other groups (P ＜ 0.05),and the prostate cancer group had a higher blood calcium content than healthy controls (P ＜ 0.05).For 25-OH-D content,bone metastases of prostate cancer group was significantly lower than the other groups (P ＜0.05).25-OH-D level showed a negative correlation with blood calcium in each group (r =0.628,P ＜ 0.05).The ROC curve showed levels of blood calcium and 25-OH-D in the diagnosis of bone metastases of prostate cancer were 0.763 and 0.712.Conclusion The high blood calcium and low vitamin D levels may be an effective predictor for bone metastases of prostate cancer.
