Serial Follow-up of White Matter Connectivity in a Patient with Progressive Multifocal Leukoencephalopathy Presenting Clinical Improvement.
- Author:
Dan Il CHUNG
1
;
Seong Il OH
;
Kyung Pil OH
;
Wonki BAEK
;
Hee Jin KIM
;
Seung Hyun KIM
Author Information
1. Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea. kimsh1@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Progressive multifocal leukoencephalopathy;
Magnetic resonance spectroscopy;
Tractography
- MeSH:
Cytarabine;
Cytosine;
Demyelinating Diseases;
Follow-Up Studies;
Humans;
Leukoencephalopathy, Progressive Multifocal;
Magnetic Resonance Spectroscopy;
Neuroimaging;
Organophosphonates;
Regeneration
- From:Journal of the Korean Neurological Association
2011;29(4):347-351
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Progressive multifocal leukoencephalopathy (PML) is a fatal disease that is characterized by progressive demyelination of the cerebral white matter due to JC viral infection. We report serial magnetic resonance spectroscopy (MRS) and tractography changes in a patient with PML. After a three-cycle treatment with cidofovir and cytarabine, the patient exhibited remarkable improvements in motor and cognitive functions. Follow-up MRS and tractography revealed regeneration of the white-matter fibers. This is the first consecutive neuroimaging study showing improvements in neurological symptoms using MRS and tractography.
