Study on ATPase activity and apoptotic-associated protein expression of chronic pressure ulcers patients with type 2 diabetes
10.7619/jcmp.201808007
- VernacularTitle:2型糖尿病患者压疮局部ATP酶活性及凋亡相关蛋白表达的研究
- Author:
Zhengjing LI
1
;
Suping BO
;
Jiamin HUANG
;
Hui SUN
;
Xiaoqin ZHOU
Author Information
1. 江苏大学附属医院 烧伤整形科
- Keywords:
type 2 diabetes;
chronic pressure ulcers;
ATPase activity;
apoptosis related proteins
- From:
Journal of Clinical Medicine in Practice
2018;22(8):21-23,27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the ATPase activity and apoptotic-associated protein expression of chronic pressure ulcers patients with type 2 diabetes.Methods A total of 43 type 2 diabetes patients with pressure sores were chosen,among whom there were 21 cases with 111 pressure sores and 22 cases with Ⅳ pressure sores,the patients who may use ATPase in the last one month (digitalis,calcium antagonists,etc.).Another Other 20 healthy volunteers were chosen as control group.ATPase activity and apoptotic associated protein expression were detected.Results Compared with the control group,the ATPase activity in the stage Ⅲ pressure sore group was decreased,Bcl-2 expression was decreased,and the expression of Bax was increased;compared with the stage Ⅲ pressure ulcer group,the ATPase activity in the stage Ⅳ pressure sore group was more significantly reduced,Bcl-2 was significantly decreased and Bax expression was significant increased.Conclusion Type 2 diabetic chronic pressure ulcers might be relevant to the decreased ATPase activity and up regulated apostosis.
