Relationship between serum free fatty acids level and insulin resistance in patients with type 2 diabetes mellitus
- VernacularTitle:2型糖尿病患者血清游离脂肪酸水平与胰岛素抵抗的关系
- Author:
Miao YU
1
;
Li ZHANG
;
Bing QIN
;
Daojun HU
Author Information
- Keywords: type 2 diabetes mellitus; free fatty acids; insulin resistance; correlation
- From: Journal of Clinical Medicine in Practice 2018;22(7):120-122
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationship between serum free fatty acids (FFA) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).Methods Totally 106 T2DM patients were selected as observation group,and 106 healthy people were selected as control group.Body mass index (BMI),FPG,FFA,HbAlc,TG,TC and HOMA-IR were compared between two groups.According to the blood glucose level,the T2DM patients were divided into good control group (n =56) and bad control group (n =50),and the FFA and HOMA-IR were compared two groups.Correlation between serum FFA and HOMA-IR in patients with T2DM was analyzed.Results In the observation group,BMI,FPG,FFA,HbA1 C,TC,TG and HOMA-IR were significantly higher than the control group (P ＜ 0.05).FFA and HOMA-IR in bad control group were significantly higher than the good control group (P ＜ 0.05).Correlation analysis showed that serum FFA was positively correlated with HOMA-IR level in T2DM patients (r =0.621,P ＜ 0.05).Conclusion Serum free fatty acids level is closely related to insulin resistance in patients with T2DM,which can reflect the blood glucose control level.
