Effect of malnutrition on cognitive function of patients with chronic obstructive pulmonary disease in stable period
10.7619/jcmp.201807033
- VernacularTitle:营养不良对稳定期慢性阻塞性肺疾病患者认知功能的影响
- Author:
Chuanqin XU
1
;
Yuanqiang HE
;
Jianhui CHEN
;
Yulong ZHENG
;
Gang LI
;
Yufeng WAN
Author Information
1. 江苏省淮安市第二人民医院呼吸内科
- Keywords:
malnutrition;
Mini Nutritional Assessment;
chronic obstructive pulmonary disease;
cognitive function
- From:
Journal of Clinical Medicine in Practice
2018;22(7):117-119,122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of malnutrition on cognitive function of patients with chronic obstructive pulmonary disease(COPD) in stable period.Methods According to score of Mini Nutritional Assessment (MNA) ＞ 17 points and ≤ 17 points,120 patients with stable COPD were divided into control group and malnutrition group.The mini-mental stat examination (MMSE) was used to detect the cognitive function of patients,and oxygen saturation,pulmonary function,serum NSE and S-100β were detected as well.Results Compared with the control group,the disease course of the malnutrition group was longer,and measured value to expected value of the first second forced expiratory volume (FEV1) and blood oxygen saturation were significantly lower,but there were no significant differences in the age and education level between the two groups (P ＞ 0.05).There were significant differences in total score,directive force,delayed memory,attention and calculating ability,recollection ability,language between two groups (P ＜ 0.05).Multiple Logistic regression analysis showed that the MMSE score was mainly related to age,education,measured value to expected value of FEV1,blood oxygen saturation,and MNA score.Both NSE and S-100β protein were negatively correlated with MMSE score (r =-0.365、-0.441,P ＜ 0.05).Conclusion Malnutrition can aggravate the cognitive impairment of COPD patients in stable stage.Serum S-100β and NSE levels may be used as predictors for cognitive impairment in COPD patients with malnutrition.
